Apistan is used to control Varroa mites. Hives should be treated twice per year for the best control of mites. Follow the instructions on the package and place one strip for every five frames of bees. Do not leave strips in the hive for longer than the recommended time and alternate treatments. Nitrile or other chemical resistant gloves should be used when handling Apistan . Apistan must be used in accordance with the instructions on the label. Apistan must be removed before placing honey supers on the hive.